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Folinic acid
🥰Excellent
Catalog No. T24403Cas No. 58-05-9
Alias Leucovorin, HSDB 6544
Folinic acid (Leucovorin) is a biofolate used in the treatment of methotrexate (MTX) toxicity reduction and as an adjuvant therapy for colon cancer.
Folinic acid
🥰Excellent
Purity: 99.7%
Catalog No. T24403Alias Leucovorin, HSDB 6544Cas No. 58-05-9
Folinic acid (Leucovorin) is a biofolate used in the treatment of methotrexate (MTX) toxicity reduction and as an adjuvant therapy for colon cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | 31 € | In Stock | |
| 25 mg | 47 € | In Stock | |
| 50 mg | 66 € | In Stock | |
| 100 mg | 95 € | In Stock | |
| 500 mg | 227 € | In Stock |
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Purity:99.7%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Folinic acid (Leucovorin) is a biofolate used in the treatment of methotrexate (MTX) toxicity reduction and as an adjuvant therapy for colon cancer. |
| In vitro | Methotrexate (MTX) alone induces a concentration-dependent increase in the percentage of micronucleated binucleated cells (MNBN) and abnormal cells (Abs). As the concentration of MTX increases, the nuclear division index (NDI) decreases. Similarly, the mitotic index (MI) also decreases at all tested concentrations of MTX. The addition of 50 μg/mL folinic acid significantly reduces the % MNBN (40-68%) and % Abs (36-77%). In the presence of 5 μg/mL folinic acid, inhibitory effects are observed as well (MNBN from 12% to 54%, Abs from 20% to 61%)[2]. |
| In vivo | Treatment with folinic acid (7.0 mg/kg; intraperitoneal injection; every other day; for 3 weeks) appears to reverse the growth inhibition induced by Methotrexate (MTX) administration in young male Balb/c mice. Long-term MTX administration is known to inhibit skeletal growth in mice[1]. |
| Alias | Leucovorin, HSDB 6544 |
| Molecular Weight | 473.44 |
| Formula | C20H23N7O7 |
| Cas No. | 58-05-9 |
| Smiles | Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)N(C=O)c2c(=O)[nH]1 |
| Relative Density. | 1.4485 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (116.17 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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